By: Jingyuan Ma Introduction This lab introduced techniques used in the Penn/Merck High-Throughput Experimentation Center. The Suzuki-Miyaura reaction was implemented using 4 reagents, an assigned inorganic base, an assigned solvent, and pre-dosed phosphine ligands. TLC and HPLC were used to qualitatively analyze the reactivity trends of 24 reaction screens, which were all conducted under room temperature and controlled settings. The following overall reaction was conducted to catalyze sp2-sp2 carbon-carbon bonding through the use of a palladium catalyst: The following is […]
